Laboratory of Chromosome Dynamics and Gene Regulation
Principal Investigator
Dr. Gunjan Mehta, Ph.D.
- Claude Bernard -
“The joy of discovery is certainly the liveliest that the mind of man can ever feel”
PUBLICATIONS
23) Wildner C#, Mehta G#, Ball D, Karpova T, Koeppl H*. Bayesian analysis dissects kinetic modulation during non-stationary gene expression. bioRxiv 2023. (https://doi.org/10.1101/2023.06.20.545522)
22) Mann R, Soota D, Das A, Podh NK, Mehta G, Notani D*. Paused polymerase synergises with transcription factors and RNA to enhance the transcritpional potential of promoters. bioRxiv 2024 (https://doi.org/10.1101/2024.10.18.618990)
21) Podh NK, Das A, Kumari A, Garg K, Yadav R, Kashyap K, Islam S, Gupta A, Mehta G*. Single-molecule tracking reveals the dynamics of Ipl1 recruitment to the kinetochores and spindles in S. cerevisiae. bioRxiv 2024 (https://doi.org/10.1101/2024.08.01.606162)
20) Reza MH, Aggarwal R, Verma J, Podh NK, Chowdhury R, Mehta G, Manjithaya R, Sanyal K*. Spindle pole body-associated Atg11, an autophagy-related protein, regulates microtubule dynamics essential for high-fidelity chromosome segregation. bioRxiv 2024 (https://doi.org/10.1101/2021.12.15.472744)
19) Kumari A, Podh NK, Sen S, Kashyap K, Islam S, Rajakumara E, Gupta, A, Nambiar M, Mehta G*. Single-Molecule Tracking dataset for histone H3 (hht1) from live and fixed cells of Schizosaccharomyces pombe. Nature Scientific Data 2024 (Accepted).
18) Paliwal S#, Dey P#, Tambat S, Shinohara A, Mehta G*. Role of ATP-dependent chromatin remodelers in meiosis. Trends in Genetics (Cell Press) 2024 (In press).
https://pubmed.ncbi.nlm.nih.gov/39550320/
17) Kinger S, Jagtap YA, Kumar P, Choudhary A, Prasad A, Prajapati VK, Kumar A, Mehta G, Mishra A*. Proteostasis in neurodegerative diseases. Advances in Clinical Chemistry 2024;121:270-333.
https://www.sciencedirect.com/science/article/abs/pii/S0065242324000635
16) Podh NK#, Das A#, Dey P, Paliwal S, Mehta G*. Single-Molecule Tracking Dataset of Histone H3 (Hht1) in Saccharomyces cerevisiae. Data in Brief 2023;47:108925.
https://pubmed.ncbi.nlm.nih.gov/36798603/
15) Podh NK#, Das A#, Dey P, Paliwal S, Mehta G*. Single-Molecule Tracking for studying protein dynamics and target-search mechanism in live cells of S. cerevisiae. STAR Protocols (Cell Press) 2022; 3(4): 101900.
https://pubmed.ncbi.nlm.nih.gov/36595957/
14) Mehta G*, Sanyal K, Suman A, Eerappa R, Ghosh SK*. Minichromosome Maintenance Proteins in Eukaryotic Chromosome Segregation. BioEssays 2022; 44(1): 0265-9247.
https://pubmed.ncbi.nlm.nih.gov/34841543/
13) Podh NK, Paliwal S, Dey P, Das A, Morjaria S, Mehta GD*. In-vivo Single-Molecule Imaging in Yeast: Applications and Challenges. Journal of Molecular Biology 2021; 433(22):167250.
https://pubmed.ncbi.nlm.nih.gov/34537238/
12) Mehta GD, Ball DA, Eriksson PR, Chereji RV, Clark DJ, McNally JG, Karpova TS. Single-Molecule analysis reveals linked cycles of RSC chromatin remodeling and Ace1 transcription factor binding in yeast. Molecular Cell 2018; 72:875-887.
https://pubmed.ncbi.nlm.nih.gov/30318444/
11) Mehta GD, Anbalagan GK, Singh AP, Gadre P, Ghosh SK. An interplay between Shugoshin and Spo13 for centromeric cohesin protection and sister kinetochore monoorientation during meiosis I in Saccharomyces cerevisiae. Current Genetics 2018; 64:1141-1152.
https://pubmed.ncbi.nlm.nih.gov/29644457/
10) Ball D#, Mehta GD#, Salomon-Kent R, Mazza D, Morisaki T, Mueller F, McNally JG, Karpova T. Single-molecule tracking of Ace1p in Saccharomyces cerevisiae defines a characteristic residence time for non-specific interactions of transcription factors with chromatin. Nucleic Acids Research 2016; 44(21);e160.
https://pubmed.ncbi.nlm.nih.gov/27566148/
9) Agarwal M, Mehta GD, Ghosh SK. Role of Ctf3 and COMA subcomplexes in meiosis: implication in maintaining Cse4 at the centromere and numeric spindle poles. Biochimica Biophysica Acta-Molecular Cell Research 2015; 1853(3);671-684.
https://pubmed.ncbi.nlm.nih.gov/25562757/
8) Mehta GD, Agarwal M, Ghosh SK. Functional characterization of kinetochore protein, Ctf19 in meiosis I: an implication of differential impact of Ctf19 on the assembly of mitotic and meiotic kinetochores in Saccharomyces cerevisiae. Molecular Microbiology 2014; 91(6):1179-1199.
https://pubmed.ncbi.nlm.nih.gov/24446862/
7) Mehta GD, Kumar R, Srivastava S, Ghosh SK. Cohesin: Functions beyond sister chromatid cohesion. FEBS Letters 2013; 587(15): 2299-2312.
https://pubmed.ncbi.nlm.nih.gov/23831059/
6) Das A, Kapoor A, Mehta GD, Ghosh SK, Sen S. Extracellular Matrix Density Regulates Extracellular Proteolysis via Modulation of Cellular Contractility. Journal of Carcinogenesis and Mutagenesis 2013; S13:003. doi: 10.4172/2157-2518.S13-003.
5) Lahiri S, Mehta GD and Ghosh SK. Iml3p, a component of the Ctf19 complex of the budding yeast kinetochore is required to maintain kinetochore integrity under conditions of spindle stress. FEMS Yeast Research 2013; 13(4): 375-385.
https://pubmed.ncbi.nlm.nih.gov/23480593/
4) Mehta GD, Rizvi SM and Ghosh SK. Cohesin: a guardian of genome integrity. Biochimica Biophysica Acta-Molecular Cell Research 2012; 1823(8): 1324-1342.
https://pubmed.ncbi.nlm.nih.gov/22677545/
3) Mehta GD, Agarwal M and Ghosh S. Centromere Identity: A challenge to be faced. Molecular Genetics and Genomics 2010; 284(2): 75-94.
https://pubmed.ncbi.nlm.nih.gov/20585957/
2) Ray S, Mehta GD and Srivastava S. Label-free detection techniques for protein microarrays: prospects, merits and challenges. Proteomics 2010; 10: 731-748.
https://pubmed.ncbi.nlm.nih.gov/19953541/
1) Singh AK, Mehta GD and Chhatpar HS. Optimization of medium constituents for improved chitinase production by Paenibacillus sp. D1 using statistical approach. Letters in Applied Microbiology 2009; 49: 708-714.
https://www.ncbi.nlm.nih.gov/pubmed/19780958
* Corresponding Author
# Co-first author